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KMID : 1025520070490030309
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Journal of Animal Science and Technology
2007 Volume.49 No. 3 p.309 ~ p.320
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Expression of Monocarboxylate Transporters (MCTs) and Basigin and Estrogen Receptor α (ERα)-Mediated Regulation of MCT1 Expression in The Efferent Ductules of Male Reproductive Tract During Postnatal Development
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Lee Ki-Ho
Choi In-Ho
Chung Chung-Soo
Chang J.-S.
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Abstract
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The purpose of the present study was to determine if monocarboxylate transporter(MCT) isoforms and Basigin(Bsg) are expressed in the efferent ductules(ED) and if MCT1 expression is under estrogen receptor(ER)α-regulation in the ED of male reproductive tract. The presence of MCT isoforms and Bsg mRNAs was detected by real-time polymerization chain reaction(PCR), and ERα-mediated regulation of MCT1 expression in the ED was indirectly determined by immuno- histochemistry. Current study found differential expression of MCT isoforms(MCT1, 2, 3, 4, and 8) and Bsg mRNAs in rat ED according to postnatal ages. In addition, comparison of MCT1 expression in the ED between wild type and ERα knockout mice at different postnatal ages showed basolateral localization of MCT1 in ciliated cells of the ED and, in part, ERα- mediated regulation of MCT1 expression. It is suggested that MCTs would play a role in regulation of function of the ED.
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KEYWORD
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Efferent ductules, Monocarboxylate transporter, Basigin
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